Matthew 10:22 - Precious Promises

And ye shall be hated of all men for my name's sake: but he that endureth to
the end shall be saved. Mat 10:22 (KJV)

The word "saved" is used here, not in the sense of the salvation of the soul
but of deliverance out of persecution. [Scofield SB]

Note that v. 22 has nothing to do with salvation from sin. It is talking
about the faithful endurance of His ambassadors during the time of
persecution in the Tribulation. This will end with the return of the Lord
(v. 23). [Wiersbe Expository Outlines]

He who holds fast faith and a good conscience to the end, till the
punishment threatened against this wicked people be poured out, he shall be
saved, preserved from the destruction that shall fall upon the workers of
iniquity. (Adam Clarke Commentary)

Christ will lead us through sufferings, to glory with him. [Matthew Henry
Commentary]

Endurance grows out of commitment to Jesus Christ. Jesus predicted that his
followers would be severely persecuted by those who hated what he stood for.
In the midst of terrible persecutions, however, they could have hope,
knowing that salvation was theirs. Times of trial serve to sift true
Christians from false or fair-weather Christians. When you are pressured to
give up and turn your back on Christ, don?t do it. Remember the benefits of
standing firm, and continue to live for Christ.
Standing firm to the end is not a way to be saved but the evidence that a
person is really committed to Jesus. Persistence is not a means to earn
salvation; it is the by-product of a truly devoted life. [Life Application
SB]

Obviously, the one who falls out of a race before reaching the goal can
never expect to receive the prize. To enter the race and to remain in it are
both essential to winning the race. It is not sufficient to begin in the
Christian way, we must remain in it "until the day of Jesus Christ" (Phil.
1:6). [SDA Commentary]

They who do not hold fast faith and a good conscience till death have no
room to hope for an admission into the kingdom of God. (Adam Clarke
Commentary)

Persecution of the most heartbreaking kind, even within families, must be
expected. Yet there must be no yielding to despair, for deliverance is
promised (cf. 24:13). [Wycliffe Bible Commentary]

 "To the end" does not specify a particular time, but rather means "endure
without breaking down." Some believers have endured, even to the point of
losing their lives. The martyrs? examples remind us that we need not give
in to pressure, but can find strength in the Lord to endure. [Victor Bible
Reader?s Companion]